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INFECTIOUS DISEASES CYCLOFERON® IN CLINICAL PRACTICE (literature review)
M.S. Savenkova

Summary. This review contains information about Cycloferon® and its use in clinical practice. The pharmacological properties of the drug, different in duration of treatment regimens, are presented. There are data on the use of Cycloferon® in severe forms of pneumonia caused by SARS-CoV and MERS-CoV (2002-2012), in various mono- and mixed acute respiratory infections. The review contains experimental data on Cycloferon®. Positive results of treatment were obtained for long-term, severe forms of tuberculosis, borreliosis, mixed herpetic infections, in often-ill children. Practice has shown that Cycloferon® can be simultaneously used in complex therapy with antibacterial and antiviral drugs .
Keywords: inducers of interferon, meglumine acridonacetates Cycloferon®, treatment regimens, infectious diseases

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ACNE IN CHILDREN
V.R. Voronina

Summary. Acne vulgaris is one of the most common skin conditions in children and adolescents, it is one of the most prevalent dermatological problems discussed at pediatrician appointments. Currently it is clear that acne patients experience significant social and psychological problems because of the disease, which determines the need for acne treatment. Symptoms of the disease, differential diagnoses and treatment approaches differ in age groups. This review also contains data on possible correlations between acne and other general diseases in varied age groups .
Keywords: pediatric acne, neonatal acne, infantile acne, mid-childhood acne, preadolescent acne

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NIGHT SLEEP DISORDERS: INFLUENCE ON THE TEENAGERS'S HEALTH
I.I. Pshenichnikova, I.N. Zakharova, V.I. Svintsitskaya, A.V. Miroshina

Summary. Sleep disturbances are associated with depression, anxiety, behavioral disorders, metabolic disorders, the risk of developing cardiovascular diseases. The use of information technologies continues to increase in adolescents. The current findings suggest that excessive screen time is associated with reduced sleep duration and sleep disturbances in adolescent. Effective interventions to decrease screen time need to be developed .
Keywords: sleep disturbance, adolescents, digital technology, health

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BIOLOGICAL THERAPY FOR INFLAMMATORY BOWEL DISEASES IN CHILDREN. APPLICATION EXPERIENCE AND NEUROLOGICAL DISORDERS
E.I. Alieva, O.A. Goryacheva, T.F. Mukhina, L.V. Glazunova, A.A. Metelina

Summary. The article reveals the concept of the term inflammatory bowel diseases, gives the basic concepts and clinical manifestations of ulcerative colitis and Crohn's disease, the criteria for diagnosis and treatment. The main biological drugs and their side effects and primarily neurological complications are discussed. We present our own data on the treatment of children with biological medicines .
Keywords: inflammatory bowel diseases, Crohn's disease, ulcerative colitis, biological therapy, infliximab, adalimumab, neuropathies

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SKIN AND MUCOUS MEMBRANE LESIONS ASSOCIATED WITH MYCOPLASMA AND HERPESVIRUS INFECTIONS IN CHILDREN
N.O. Kuvardina, F.S. Kharlamova, O.V. Shamsheva, I.V. Polesko, I.M. Osmanov, E.R. Samitova, Yu.V. Romanova, O.S. Ostapushchenko

Summary. The relevance of the study is due to the growing number of Mycoplasma strains, that form resistance to macrolides, which contributes to the wide spread of persistent variants of the course of mycoplasmosis with the development of extra-respiratory lesions of various organs and systems. Among which pediatricians often register skin lesions, which in previous years were mostly regarded by dermatologists and allergologists as allergodermatoses .
Keywords: extra-respiratory lesions in mycoplasmosis combined with herpesvirus infection, vasculitis, urticaria, vesicular vasculitis, mucositis, ring-shaped, nodular erythema, Stevens-Johnson syndrome, necrotic epidermal necrolysis, multiform exudative erythema, autoantibodies to endothelial and vascular smooth muscle antigens

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TO HELP THE DOCTOR HOW CAN A PEDIATRICIAN WRITE A REPORT ON THEIR PROFESSIONAL ACTIVITIES (PORTFOLIO)?
I.M. Osmanov, S.N. Borzakova, A.V. Vinokurov

Summary. In order to extend the admission of a doctor to professional activity, from January 1,2021, it is planned to introduce periodic accreditation of specialists, which will be carried out once every 5 years. Periodic accreditation includes one stage – portfolio assessment. The process of obtaining admission to the professional activity of a doctor involves assessment of his professional knowledge, practical skills and clinical experience. The main tool for solving this problem is portfolio analysis, including the report on professional activities. Currently, the submission of a doctor's report is required during certification for the acquisition / confirmation of a qualification category, a portfolio is required for obtaining the status of "Moscow doctor". The current regulatory documents on the certification and accreditation of specialists do not contain detailed information on the form and content of such reports, which can cause significant difficulties for doctors in their preparation and for members of certification commissions in assessing their content. The authors reviewed the regulatory and methodological documents on this issue and analyzed the medical reports submitted to the expert certification group for the acquisition/extension of the qualification category of specialists with higher medical education in the specialty "Pediatrics" of the Moscow Department of Health for the first half of 2020. Based on the analysis, recommendations were formulated for the preparation of a specialist's report, which would improve the efficiency of its use for assessing the qualifications of a doctor .
Keywords: assessment of the qualifications of a doctor, admission of a doctor to professional activity, report on professional activity, accreditation of medical specialists, acquisition of a medical category, professional portfolio of a doctor, regulatory framework for doctor's activities, pediatrician, district pediatrician

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DIAGNOSIS OF DISEASES OF THE URINARY SYSTEM IN YOUNG CHILDREN
E.A. Yurieva, M.V. Kushnareva, V.V. Dlin, E.S. Vozdvizhenskaya

Summary. Nephropathy is rather frequent and in some cases life-threatening pathology in infants. Risk factors for inflammatory and/or dysmetabolic manifestations in this age group of infants are anatomical and genetic abnormalities of the urinary system, their morphofunctional dismaturity. Risk factors also include hypoxic damage to the kidneys, consequences of resuscitation, kidney disease and urinary tract infections in mothers. A timely diagnosis and an adequate therapy prevents the chronic of nephropathy and the early development of chronic renal failure .
Keywords: organs of the urinary system, nephropathy, infants, babies, early age

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PROSPECTS FOR VACCINE PREVENTION OF ROTAVIRUS INFECTION
L.N. Mazankova, S.G. Gorbunov, O.S. Bitkova

Summary. The article presents data on the incidence of rotavirus infection in young children, features of its immunopathogenesis, clinical course and outcomes, which indicates the relevance of this problem for public health. The possibilities of immunoprophylaxis as an effective and safe method of controlling rotavirus infection in modern conditions are shown .
Keywords: vaccination, rotavirus infection, immunopathogenesis, children